Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Karyopherin Beta (KPNb1) in samples from tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species.

Description: Recombinant Human Karyopherin Beta expressed in: E.coli

Description: A sandwich ELISA kit for detection of Karyopherin Beta from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

Description: A Rabbit polyclonal antibody against Human Karyopherin Beta (KPNb1)

Description: A Rabbit polyclonal antibody against Human Karyopherin Beta (KPNb1). This antibody is labeled with APC.

Description: A Rabbit polyclonal antibody against Human Karyopherin Beta (KPNb1). This antibody is labeled with Biotin.

Description: A Rabbit polyclonal antibody against Human Karyopherin Beta (KPNb1). This antibody is labeled with Cy3.

Description: A Rabbit polyclonal antibody against Human Karyopherin Beta (KPNb1). This antibody is labeled with FITC.

Description: A Rabbit polyclonal antibody against Human Karyopherin Beta (KPNb1). This antibody is labeled with HRP.

Description: A Rabbit polyclonal antibody against Human Karyopherin Beta (KPNb1). This antibody is labeled with PE.

Description: KPNB1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 899 amino acids (1-876 a.a.) and having a molecular mass of 99.6kDa. ;KPNB1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Description: A Rabbit polyclonal antibody against Human Karyopherin Beta (KPNb1). This antibody is labeled with APC-Cy7.

Description: Mouse polyclonal to Karyopherin beta 3

Description: Karyopherin Peptide

Description: Description of target: Functions in nuclear protein import, either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (NLS) in cargo substrates, or by acting as autonomous nuclear transport receptor. Acting autonomously, serves itself as NLS receptor. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In association with IPO7 mediates the nuclear import of H1 histone. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. Imports SNAI1 and PRKCI into the nucleus.4 Publications <p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More…</a></p> Manual assertion based on experiment iniRef.13"Importin beta, transportin, RanBP5 and RanBP7 mediate nuclear import of ribosomal proteins in mammalian cells."_x005F_x005F_x000D_Jaekel S., Goerlich D._x005F_x005F_x000D_EMBO J. 17:4491-4502(1998) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, INTERACTION WITH RPL23A; RPS7; RPL5 AND IPO7.Ref.14"The importin beta/importin 7 heterodimer is a functional nuclear import receptor for histone H1."_x005F_x005F_x000D_Jaekel S., Albig W., Kutay U., Bischoff F.R., Schwamborn K., Doenecke D., Goerlich D._x005F_x005F_x000D_EMBO J. 18:2411-2423(1999) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, INTERACTION WITH H1 HISTONE AND IPO7.Ref.19"Phosphorylation of tyrosine 256 facilitates nuclear import of atypical protein kinase C."_x005F_x005F_x000D_White W.O., Seibenhener M.L., Wooten M.W._x005F_x005F_x000D_J. Cell. Biochem. 85:42-53(2002) [PubMed] [Europe PMC] [Abstract]Cited for: INTERACTION WITH PRKCI, FUNCTION, SUBCELLULAR LOCATION.Ref.30"Characterization of Snail nuclear import pathways as representatives of C2H2 zinc finger transcription factors."_x005F_x005F_x000D_Mingot J.M., Vega S., Maestro B., Sanz J.M., Nieto M.A._x005F_x005F_x000D_J. Cell Sci. 122:1452-1460(2009) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, INTERACTION WITH SNAI1 AND SNAI2. ;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: < 0.28 ng/mL

Description: Mouse monoclonal to Karyopherin beta 3

Description: Recombinant Mouse Importin subunit beta-1(Kpnb1) expressed in E.coli